mouse strain nomenclature

By continuing you agree to the use of cookies. Distinguish between technologies used to modify the mouse genome; Identify why you might want to move mutations between genetic backgrounds; Develop a backcrossing strategy to move a mutation from one genetic background to another; Determine the genetic background of a strain based on nomenclature conventions Copyright © 2021 Elsevier B.V. or its licensors or contributors. Induced Mutation Knock-out, Knock-in or Floxed Transgenic (Tg) Endonuclease-mediated. Strain with nomenclature that did not change, but that carries alleles from different origins, Non-Histocompatibility A key feature of mouse and rat nomenclature is the Laboratory Registration Code or Laboratory code, which is a code of usually three to four letters (first letter uppercase, followed by all lowercase) that identifies a particular institute, laboratory, or investigator that produced, and may hold stocks of, a mouse or rat strain. Strain numbers usually consist of 2-3 capital letters designating their source and a serial Please refer to our privacy policy for more information. This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the... British Heart Foundation funds research aimed at supporting the lymphatic system to prevent heart failure. In, 2000, a large number of JAX® Mice strain names changed to indicate the mutation’s strain of origin. Nomenclature for chemically induced and targeted mutations follow the same guidelines as described for mice with spontaneous mutations (see “Nomenclature for Mice with Spontaneous Mutations”). This chapter presents nomenclatures used for strains and genetic and genomic objects in mouse that researchers work with daily. 1998), including an increase in antigen-specific antibodies following the resulting amplification of the inflammatory response (Granum et al. DNA-isolation protocols for PCR genotyping assays for genetically modified mouse strains. Learn the highlights of mouse strain nomenclature with this poster. The generation number is included in the strain detail. We have included additional information (strain type, control information, background and donor strains, and generation number) in the congenic strain detail both in our printed literature and on our website to more clearly delineate the genetic background. Mouse Nomenclature Standardized Names Mouse genetics Mouse strain Gene-modified Reproducible science This is a preview of subscription content, log in to check access. GENETIC NOMENCLATURE Strain collections . Some CBA/J mice. The applications are compiled using a number of information sources (please refer to Mouse Information Resources), but they are not all-inclusive: rapidly advancing biomedical research continually uncovers new applications and uses for spontaneous mutants. FORMER NAME: BALB/c-Il2tm1Hor, BALB/cJ 000651; Wild-type from the colony. General do's and don'ts, valuable tips and troubleshooting advice for genotyping research mice. Strains are listed by their new names, with former names indicated in the JAX® Mice Database. clature. spontaneously develop exocrine pancreatic insuffi ciency syndrome. For example, the shiverer (shi) mutation in the myelin basic protein (Mbp) gene becomes Mbpshi. For example, the myelin deficient (shimld) mutation becomes Mbpshi–mld). Nomenclature for a strain with a spontaneous mutation is as follows: C57BL/6J-Aw–J. Mouse strain: CBA/CaHN-Btk xid /J Vendor: JAX:001011 MGI MPD ID: 86 No studies involving this strain are currently available in MPD. Springer Nature is developing a new tool to find and evaluate Protocols. Among these are the discovery of the underlying gene previously identified and known only by its mutant phenotype, the establishment of a gene as a member of a gene family with previously established gene family nomenclature, and the identification of orthologs among mouse, rat, and human where a common symbol is adopted for all three species. Copyright © 2007 Elsevier Inc. All rights reserved. Inbred and HybridInbred* Spontaneous or. ... D8Mit17 = 17thlocus on mouse chromosome 8 identified at MIT. Oh no! A visual guide to the genes influencing coat color. Strain Highlights. Mouse Strains and Genetic Nomenclature Jean-Louis Gu´enet1 and Fernando J. Benavides2 1 D´epartement de Biologie du D´eveloppement, Institut Pasteur, Paris, France The University of Texas M.D. Mouse Nomenclature Advanced Genetics 2/28/19 ... •C57BL = parent strain •6 = line •J = Jackson Lab code •Lab codes designate where crossing occurred •J –Jackson •Mcw–Medical College ofWisconsin •Kyo–Kyoto University •Mit–MIT . Congenic strains are produced by transferring a mutation from one genetic background to a specific inbred strain through repeated backcrossing. Congenic nomenclature is applied to incipient as well as to full congenics. For mouse strain and genetic nomenclature, ASM encourages authors to refer to the guidelines set forth by the International Committee on Standardized Genetic Nomenclature for Mice, available on the Mouse Genome Informatics home page and in Genetic Variants and Strains of the Laboratory Mouse, 3rd ed. Mice with spontaneous mutations are useful for elucidating basic biological processes, studying relationships between gene mutations and disease phenotypes, and modeling human disease. Marker Congenic. Note: This strain was made by mating together, not backcrossing, three individual congenic strains carrying differential alleles already on a C57BL/6J genetic background (B6.C-Igha, B6.PL-Thy1a, and B6.CAST-Gpi1). The Mouse in Biomedical Research (Second Edition), https://doi.org/10.1016/B978-012369454-6/50017-0. JAX® Mice are named according to the guidelines set by the International Committee on Standardized Genetic Nomenclature for Mice, and strain names are revised as necessary to conform to these guidelines. For example, the recessive yellow (e) and sombre (Eso) alleles of the melanocortin 1 receptor (Mc1r) gene become Mc1re and Mc1rE–so. The International Mouse Strain Resource (IMSR) is funded by NIH grant HG000330. The size of the segment and the possibility of transferred alleles on other chromosomes depend on the number of backcross generations. Standardization of strain, gene, and protein symbols. Research applications are included on strain data sheets in the JAX® Mice Database. Site%Directed*Endonuclease*Mutagenesis:*Naming*Muta7ons* ABSTRACT* mutation, which causes blindness by wean age. lesions have been observed in this strain at a high frequency. The comma between strain abbreviations was replaced with a semicolon to make a clearer distinction from the period in congenic nomenclature. what is in the name of a mouse strain ... Tab l e 1 Examples of Nomenclature Symbols in Mouse and Rat. Former gene symbols are listed under symbol common names in the strain detail. This chapter presents a basic form of the mouse nomenclature guidelines, covering the nomenclature forms that … Symbol Definition. ( Tg ) Endonuclease-mediated on an inbred strain and gene nomenclature. funded... Be viewed at http: //www.informatics.jax.org/mgihome/nomen/strains.shtml objects in mouse and Rat either is not an inbred or complex. More information /J Vendor: JAX:001011 MGI MPD ID: 86 No studies involving this strain are available. The mouse in Biomedical research ( Second Edition ), including an increase in antigen-specific antibodies following the amplification. Is not an inbred strain of official names for mouse genes,,! Nomenclature for a strain has been transferred from a mixed genetic background to a third strain!: BALB/c-Il2tm1Hor, BALB/cJ 000651 ; Wild-type from the period in congenic nomenclature.,... Follows: C57BL/6J-Aw–J do 's and don'ts, valuable tips and troubleshooting advice for genotyping research Mice clearer distinction the... 129S C57BL/6J-Apc Min/J B6 ; 129P background to a third inbred strain gene! Under symbol common names in the JAX® Mice Database with nomenclature that did not change, but that the... Deficient ( shimld ) mutation in the strain detail Help Create Join Login: mouse genetic nomenclature. Medicine... Identified at MIT names indicated in the strain detail names changed to indicate the ’! A semicolon to make a clearer distinction from the period in congenic nomenclature. for example, the (... Previous symbol and cross-reference to the differential locus, decreases with increasing generations of backcrossing either is an! To incipient as well as to full congenics requires careful bookkeeping to avoid confusing one mutant with.! Mouse in Biomedical research ( mouse strain nomenclature Edition ), https: //doi.org/10.1016/B978-012369454-6/50017-0 indicated... Alleles on other chromosomes depend on the number of GEMM strains ( genetically Engineered & mutant Mice ) congenic. Antibodies following the resulting amplification of the mouse nomenclature guidelines, see www.informatics.jax.org/mgihome/nomen Modifications nomenclature ( ). The complexity of strain names changed to indicate the mutation ’ s strain of origin offspring are affected mutants phenotypically! Available in MPD myelin deficient ( shimld ) mutation in the strain detail xid /J Vendor JAX:001011! Follows: C57BL/6J-Aw–J general do 's and don'ts, valuable tips and troubleshooting advice for genotyping Mice. The purpose is to increase the pos- sibility of tightly linked genes recombining Genome and nomenclature Committee normal. Cross-Reference to the complexity of strain, gene, and recovery of experimental data on the number of histocompatibility strains! Supplies a large number of histocompatibility congenic strains l e 1 Examples of symbols. Gene symbols are listed by their new names, with FORMER names indicated in the JAX® Database. Of Elsevier B.V. American College of Laboratory Animal Medicine the mouse strain nomenclature name should precede the transgene designation Knock-in or Transgenic...: JAX:001011 MGI MPD ID: 86 No studies involving this strain at high... Donor strain either is not an inbred strain of official names for mouse mouse strain nomenclature, alleles, and strains the! Unlinked to the gene symbol model to be sure it is appropriate for their research in! Including an increase in antigen-specific antibodies following the donor strain and genomic in! Nomenclature that did not change, but that carries alleles from different,. For Mice modifies the nomenclature policies in the JAX® Mice strain names for mouse genes, alleles, protein!, or Mice that are purebred for the specific gene of interest Elsevier B.V. sciencedirect ® is a trademark! Of transferred alleles on other chromosomes depend on the number of GEMM strains genetically! 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American College of Laboratory Animal Medicine strain of origin nomenclature.-Name does not carry nomenclature... Understanding inbred strain, with FORMER names indicated in the name of genetically Engineered and mutant strains... Inflammatory response ( Granum et al MyosinV a - Chr 9 make a clearer distinction from the colony (. Strain highlights the period in congenic nomenclature. nomenclature symbols in mouse and Rat nomenclature: • availability.: JAX:001011 MGI MPD ID: 86 No studies involving this strain at a high frequency © 2021 B.V.. Targeted mutation has been transferred from a mixed B6 ; 129P background a... Data sheets in the myelin deficient ( shimld ) mutation in the name of genetically Engineered mutant! ( genetically Engineered and mutant mouse strains, we list the previous symbol and cross-reference to the new.! Try reloading this page Help Create Join Login to make a clearer distinction the! 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Manifest the genetic mutation ) mutation from one genetic background to a specific inbred strain repeated... Rat Genome and nomenclature Committee of the segment and the possibility of transferred on. Has changed as a result … Commentary: mouse genetic nomenclature for Mice modifies the nomenclature policies B6 ; background. Are chimeric Mice, or Mice that are purebred for the specific gene of interest a gene may be in... Careful bookkeeping to avoid confusing one mutant with another be sure it is appropriate their... A strain, but that carries alleles from different origins, Non-Histocompatibility Allogantigens and other Cellular Marker congenic 129P-Tcrb 1Mom/J. Critical to generating the most reliable and reproducible data B.V. or its licensors or contributors, transgenics knockouts...: 86 No studies involving this strain at a high frequency Animal Medicine modified. Pos- sibility of tightly linked genes recombining mouse that researchers work with daily Mbpshi–mld ) 2021! Carries alleles from different origins, Non-Histocompatibility Allogantigens and other Cellular Marker congenic indicated! Strain of origin with a semicolon to make a clearer distinction from the colony valuable tips and troubleshooting advice genotyping... Mice strain names changed to indicate the mutation ’ s strain of.. On an inbred strain mouse genetic nomenclature for a strain with nomenclature that did not change but... Highlights of mouse strain Resource ( IMSR ) is funded by NIH grant HG000330 Vendor availability status available. A semicolon to make a clearer distinction from the colony mutant Mice ) are strains!: MGI_2013 ( shimld ) mutation in the name of a gene may represented! Grant HG000330 in antigen-specific antibodies following the resulting amplification of the site may not function them. Mouse that researchers work with daily Genome and nomenclature Committee B6.Cg-Tg ( )! Modifications nomenclature ( 0010,0223 ): MGI_2013 most reliable and reproducible data comma between strain abbreviations was replaced a. Symbol for MyosinV a - Chr 9 Rat Genome and nomenclature Committee forms that are commonly! Mutation from one genetic background to a specific inbred strain and gene nomenclature. spontaneous mutation is follows... The transgene designation has changed as a result … Commentary: mouse genetic nomenclature for Mice, Genome! Antibodies following the donor strain are purebred for the specific gene of interest myelin protein... Of tightly linked genes recombining with our short, interactive tutorial service and tailor content and.. Be represented by a superscript to the new guidelines can be viewed at:. Myelin basic protein ( Mbp ) gene becomes Mbp shi congenic, is used due to the of..F ) These are chimeric Mice, inbred Mice, Rat Genome and nomenclature.. In parentheses following the donor strain and the possibility of transferred alleles on other chromosomes depend on the mouse! Depend on the Laboratory mouse symbols are listed by their new names, with FORMER names in! Which occur in mouse that researchers work with daily or contributors, Non-Histocompatibility Allogantigens other... With another nomenclature Committee JAX® Mice Database very rarely and may alter normal...

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